منابع مشابه
Adenosine receptors and cancer.
The A(1), A(2A), A(2B) and A(3) G-protein-coupled cell surface adenosine receptors (ARs) are found to be upregulated in various tumor cells. Activation of the receptors by specific ligands, agonists or antagonists, modulates tumor growth via a range of signaling pathways. The A(1)AR was found to play a role in preventing the development of glioblastomas. This antitumor effect of the A(1)AR is m...
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Adenosine acts as neuromodulator in the brain, which its involvement in a wide range of brain processes and diseases has been studied, such as epilepsy, sleep, anxiety, panic disorder, Alzheimer’s disease, Parkinson’s disease and schizophrenia. Adenosine receptors have been detected: A1R, A2AR (A2AR), A2BR, and A3R. A1R and A2R inhibit cAMP production, while A2AR and A2BR stimulate cAMP product...
متن کاملThe role of adenosine A3 receptors in cytotoxicity of the breast cancer cell lines
The nucleoside adenosine is present within cells and body fluids of all living organisms and its production, both intra- and extracellularly, is tightly coupled to energy consumption resulting in increased level of extracellular adenosine. The physiological effects of adenosine are mediated through four pharmacologically and biochemically distinct adenosine receptors (AR), i.e. A1, A2A, A2B and...
متن کاملAdenosine and adenosine receptors in rheumatoid arthritis
Rheumatoid arthritis is one of the most important chronic, progressive and disabling inflammatory diseases characterized by joint destructive process associated with synovial proliferation and secretion of high levels of proinflammatory mediators including cytokines and growth factors. Early diagnosis and effective therapy are crucial in order to prevent unfavorable outcome with joint deteriora...
متن کاملAdenosine receptors and angiogenesis.
Copyright © 2007 American Heart Association. All rights reserved. Print ISSN: 0009-7330. Online TX 72514 Circulation Research is published by the American Heart Association. 7272 Greenville Avenue, Dallas, DOI: 10.1161/CIRCRESAHA.107.165761 2007;101;1075-1077 Circ. Res. John A. Auchampach Adenosine Receptors and Angiogenesis http://circres.ahajournals.org/cgi/content/full/101/11/1075 located on...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2011
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2010.09.020